More than high standards needed

Replication: Needed Now More Than Ever.

[Generalists are needed more than ever].

15 If today you want to keep up with basic and clin‐ ical research, you need to concentrate on a very small field and reach tremendous depths in this very field. And, actually, life is too short to also accumulate the knowledge necessary to do mean‐ ingful scientific work even on closely related top‐ ics. Hence, specialization is inevitable not only in research; it was a prerequisite for the de...

More than Zero Intelligence Needed for Continuous Double-Auction Trading

Gode & Sunder's (1993) results from using \zerointelligence" (zi) traders, that act randomly within a continuous double-auction (cda) market, appear to imply that human-like convergence to the theoretical equilibrium price in such markets is determined more by market structure than by the intelligence of the traders in that market. This paper presents a mathematical analysis that predicts serio...

Bench-to-bedside review: Human subjects research – are more standards needed?

There are many controversial issues surrounding ethics in study design and conduct of human subjects research. In this review we briefly touch on the origin of ethics in clinical research and how the current regulations and standards came into practice. We then discuss current controversies regarding informed consent, conflicts of interest, institutional review boards, and other relevant issues...

Home overnight pulse oximetry in patients with COPD: more than one recording may be needed.

STUDY OBJECTIVES Home overnight pulse oximetry (OPO) is used to assess nocturnal desaturation in patients with COPD, but the current practice of relying on one recording has not been studied. We assessed the variability of nocturnal desaturation in patients with COPD between nights, as measured by home OPO. DESIGN Study subjects attended for clinical evaluation, spirometry, and arterial blood...